Epistasis and the release of genetic variation during long-term selection. Academic Article

abstract

• It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.

authors

• Andersson, Leif

published proceedings

• Nat Genet

altmetric score

• 8.538

author list (cited authors)

• Carlborg, O., Jacobsson, L., Ahgren, P., Siegel, P., & Andersson, L.

citation count

• 258

complete list of authors

• Carlborg, Orjan||Jacobsson, Lina||Ahgren, Per||Siegel, Paul||Andersson, Leif

publication date

• April 2006

publisher

• Springer Nature  Publisher

published in

• Nature Genetics  Journal

keywords

• Animals
• Body Weight
• Chickens
• Epistasis, Genetic
• Genetic Variation
• Quantitative Trait Loci
• Selection, Genetic

PubMed Central ID

• 16532011

Digital Object Identifier (DOI)

• 10.1038/ng1761

start page

• 418

end page

• 420

volume

• 38

issue

• 4

URL

• http://dx.doi.org/10.1038/ng1761