ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals.

abstract

• A DNA transposon integrated into -the genome of a primitive mammal some 200 million years ago and, millions of years later, it evolved an essential function in the common ancestor of all placental mammals. This protein, now named ZBED6, was recently discovered because a mutation disrupting one of its binding sites, in an intron of the IGF2 gene, makes pigs grow more muscle. These findings have revealed a new mechanism for regulating muscle growth as well as a novel transcription factor that appears to be of major importance for transcriptional regulation in placental mammals.

authors

• Andersson, Leif

published proceedings

• Transcription

author list (cited authors)

• Andersson, L., Andersson, G., Hjlm, G., Jiang, L., Lindblad-Toh, K., Lindroth, A. M., ... Sundstrm, E.

citation count

• 15

complete list of authors

• Andersson, Leif||Andersson, Göran||Hjälm, Göran||Jiang, Lin||Lindblad-Toh, Kerstin||Lindroth, Anders M||Markljung, Ellen||Nyström, Anna-Maja||Rubin, Carl-Johan||Sundström, Elisabeth

publication date

• November 2010

publisher

• Taylor & Francis  Publisher

published in

• Transcription  Journal

keywords

• 1 Underpinning Research
• 1.1 Normal Biological Development And Functioning
• Biotechnology
• Genetics
• Human Genome

PubMed Central ID

• 21326889

Digital Object Identifier (DOI)

• 10.4161/trns.1.3.13343

start page

• 144

end page

• 148

volume

• 1

issue

• 3

URL

• http://dx.doi.org/10.4161/trns.1.3.13343