Linkage of the equine serum esterase (Es) and mitochondrial glutamate oxaloacetate transaminase (GOTM) loci. A horse-mouse homology. Academic Article

abstract

• Three previously described electrophoretic phenotypes of mitochondrial glutamate oxaloacetate transaminase (GOTM) in horse leukocytes are shown to be controlled by two codominant alleles at a single autosomal locus. The GOTM locus is linked to the serum esterase locus (Es), as no recombination between these loci was observed among 16 informative offspring in one sire family. The results assign GOTM to equine linkage group (LG) II. The hypothesis that a part of LG II (e-Es) shares homologies with mouse chromosome 8 is thus confirmed, as the murine homologue of GOTM is located within the cluster of esterase loci on chromosome 8. The assumed homology also involves rabbit LG VI, rat LG V, and human chromosome 16. The observation is a striking example of the conservation of linkage relationships between mammalian species.

authors

• Andersson, Leif

published proceedings

• J Hered

author list (cited authors)

• Andersson, L., Sandberg, K., Adalsteinsson, S., & Gunnarsson, E.

citation count

• 10

complete list of authors

• Andersson, L||Sandberg, K||Adalsteinsson, S||Gunnarsson, E

publication date

• September 1983

publisher

• Oxford University Press (OUP)  Publisher

published in

• JOURNAL OF HEREDITY  Journal

keywords

• Animals
• Aspartate Aminotransferases
• Chromosome Mapping
• Esterases
• Female
• Genetic Linkage
• Horses
• Humans
• Male
• Mice
• Mitochondria
• Rabbits
• Rats
• Species Specificity

PubMed Central ID

• 6630998

Digital Object Identifier (DOI)

• 10.1093/oxfordjournals.jhered.a109811

start page

• 361

end page

• 364

volume

• 74

issue

• 5

URL

• http://dx.doi.org/10.1093/oxfordjournals.jhered.a109811