Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross. Academic Article

abstract

• The melanocortin-4 receptor (MC4R), a G-protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R missense mutation (Asp298Asn) and fatness, growth and feed intake in pigs. To assess this association further, we analysed the segregation of this missense mutation in relation to variation in fatness traits using a Wild Boar x Large White intercross. The Wild Boar and Large White founders were homozygous for different MC4R alleles. The MC4R was assigned to the expected region on pig chromosome 1. The statistical evaluation did not reveal any indication of a significant effect on fatness related traits in this pedigree.

authors

• Andersson, Leif

published proceedings

• Anim Genet

author list (cited authors)

• Park, H. B., Carlborg, O., Marklund, S., & Andersson, L.

citation count

• 48

complete list of authors

• Park, HB||Carlborg, O||Marklund, S||Andersson, L

publication date

• April 2002

publisher

• Wiley  Publisher

published in

• Animal Genetics  Journal

keywords

• Animals
• Body Weight
• Crosses, Genetic
• Genotype
• Least-Squares Analysis
• Linear Models
• Receptor, Melanocortin, Type 4
• Receptors, Corticotropin
• Swine

PubMed Central ID

• 12047230

Digital Object Identifier (DOI)

• 10.1046/j.1365-2052.2002.00824.x

start page

• 155

end page

• 157

volume

• 33

issue

• 2

URL

• http://dx.doi.org/10.1046/j.1365-2052.2002.00824.x