Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.

abstract

• The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.

authors

• Andersson, Leif

published proceedings

• Nat Genet

altmetric score

• 12.746

author list (cited authors)

• Salmon Hillbertz, N., Isaksson, M., Karlsson, E. K., Hellmn, E., Pielberg, G. R., Savolainen, P., ... Andersson, G.

citation count

• 160

complete list of authors

• Salmon Hillbertz, Nicolette HC||Isaksson, Magnus||Karlsson, Elinor K||Hellmén, Eva||Pielberg, Gerli Rosengren||Savolainen, Peter||Wade, Claire M||von Euler, Henrik||Gustafson, Ulla||Hedhammar, Ake||Nilsson, Mats||Lindblad-Toh, Kerstin||Andersson, Leif||Andersson, Göran

publication date

• November 2007

publisher

• Springer Nature  Publisher

published in

• Nature Genetics  Journal

keywords

• Animals
• Dermoid Cyst
• Dog Diseases
• Dogs
• Female
• Fibroblast Growth Factor 3
• Fibroblast Growth Factor 4
• Fibroblast Growth Factors
• Gene Duplication
• Genetic Predisposition To Disease
• Genotype
• Male
• Neoplasm Proteins
• Phenotype
• Skin Abnormalities
• Spina Bifida Occulta

PubMed Central ID

• 17906623

Digital Object Identifier (DOI)

• 10.1038/ng.2007.4

start page

• 1318

end page

• 1320

volume

• 39

issue

• 11

URL

• http://dx.doi.org/10.1038/ng.2007.4