Genomic approaches to the improvement of disease resistance in farm animals. Academic Article

abstract

• As a result of the difficulties in improving disease resistance in farm animals by traditional phenotype selection, the achievement of such improvement is one of the most important applications of genome research. The major hurdle to this important goal is the collection of informative disease records to enable the segregation of disease resistance loci (DRL) to be traced in pedigrees. This paper reviews the principles for DRL identification by association analyses or by linkage analyses. Once linkage has been established, the location of the DRL may be further refined, a process which may eventually lead to the molecular characterisation of the causative gene(s) and mutation(s). A reliable map assignment of a DRL is sufficient for the practical utilisation of this knowledge, since the inheritance of the DRL can be traced by flanking markers. Marker-assisted selection concerns the use of linked markers for selection within populations, while marker-assisted introgression is used if DRL alleles are introgressed from a donor (resource) population.

authors

• Andersson, Leif

published proceedings

• Rev Sci Tech

author list (cited authors)

• Soller, M., & Andersson, L.

citation count

• 27

complete list of authors

• Soller, M||Andersson, L

publication date

• April 1998

publisher

• O.I.E (World Organisation for Animal Health)  Publisher

published in

• OIE Revue Scientifique et Technique  Journal

keywords

• Animals
• Animals, Domestic
• Breeding
• Chromosome Mapping
• Cloning, Molecular
• Disease
• Disease Resistance
• Genetic Linkage
• Genetic Markers
• Genome
• Genome Analysis
• Genotype
• Immunity, Innate
• Marker-assisted Selection
• Phenotype
• Selection, Genetic

PubMed Central ID

• 9638821

Digital Object Identifier (DOI)

• 10.20506/rst.17.1.1102

start page

• 329

end page

• 345

volume

• 17

issue

• 1

URL

• http://dx.doi.org/10.20506/rst.17.1.1102