The chemotherapeutic efficacy of imidocarb dihydrochloride on concurrent bovine anaplasmosis and babesiosis. I. The effects of a single treatment. Academic Article

abstract

• The chemotherapeutic efficacy of imidocarb dihydrochloride (3,3-bis(2-imidazolin-2 yl) carbanilide dihydrochloride) administered as single intramuscular doses of 10, 20 and 25 mg/kg, against concurrent bovine anaplasmosis and babesiosis, is reported. Dosages of 20 and 25 mg/kg of imidocarb dihydrochloride rapidly inhibited acute ascending concurrent parasitaemias of Anaplasma marginale, Babesia bigemina and Babesia argentina; however, 10 mg/kg had a minimal effect on A. marginale but was very effective against B. bigemina and B. argentina. Imidocarb dihydrochloride at 10, 20 and 25 mg/kg inhibited the development of immunity of the acute Babesia spp. infections, making the calves more susceptible to babesiosis upon challenge. The inhibition of A. marginale parasitaemias was directly related to increasing doses of imidocarb dihydrochloride; however, recrudescing and persisting post-treatment parasitaemias also occurred more frequently at higher doses. 1974 E. & S. Livingstone Ltd.

authors

• Adams, Leslie

published proceedings

• Trop Anim Health Prod

author list (cited authors)

• Adams, L. G., & Todorovic, R. A.

citation count

• 6

complete list of authors

• Adams, LG||Todorovic, RA

publication date

• May 1974

publisher

• Springer Nature  Publisher

published in

• Tropical Animal Health and Production  Journal

keywords

• Anaplasma
• Anaplasmosis
• Animals
• Anti-Bacterial Agents
• Babesia
• Babesiosis
• Blood
• Cattle
• Cattle Diseases
• Complement Fixation Tests
• Hematocrit
• Injections, Intramuscular
• Injections, Intravenous
• Male
• Recurrence

PubMed Central ID

• 4416121

Digital Object Identifier (DOI)

• 10.1007/BF02380541

start page

• 71

end page

• 78

volume

• 6

issue

• 2

URL

• http://dx.doi.org/10.1007/bf02380541