2010 Elsevier Ltd. All rights reserved. Leaner mice carry a spontaneous, autosomal recessive mutation that maps to the Cacna1a gene, which codes for the 1A calcium channel pore-forming subunit of Cav2.1 (P/Q-type) voltage-gated calcium ion channels. Leaner mice exhibit cerebellar ataxia, absence epilepsy and paryoxysmal dyskinesia, and severe cerebellar atrophy, resulting from the degeneration of approximately half of the cerebellar granule, Purkinje, and Golgi cells.
