Liposome delivery of NMR contrast agents for improved tissue imaging. Academic Article uri icon

abstract

  • Large unilamellar liposomes containing the paramagnetic contrast agent manganese chloride were shown to selectively enhance the intensity of the proton NMR signal from the livers of experimental mice. The kinetics of the observed effect indicate that the liposomes are rapidly removed from the circulation and deposited in high concentration within the liver. This process is known to involve the phagocytic activity of macrophages. These results show that liposomes could provide a useful and efficient vehicle for delivering NMR contrast agents to organs like the liver, spleen, and bone marrow. It may also be possible to use liposomes to selectively deliver contrast agents to tissue regions of developing pathology that are rich in macrophage activity.

published proceedings

  • Magn Reson Med

author list (cited authors)

  • Magin, R. L., Wright, S. M., Niesman, M. R., Chan, H. C., & Swartz, H. M.

citation count

  • 74

complete list of authors

  • Magin, RL||Wright, SM||Niesman, MR||Chan, HC||Swartz, HM

publication date

  • June 1986

publisher