Hormonal modulation of ovarian interstitial cells with particular reference to gap junctions. Academic Article

abstract

• Thin-section and freeze-fracture studies on the rat ovarian interstitial cells revealed reductions in the size and the number of gap junctions after pituitary ablation. Small gap junctions, however, persist as long as 90 days after hypophysectomy even though regressive cytoplasmic changes are completed 75 d earlier. Administration of exogenous human chorionic gonadotrophin (HCG) results in the restoration of the normal interstitial cell morphology which is accompanied by amplification of junctional membrane. Within 24 h of hormone application, gap junction growth is characterized by the appearance of formation plaques. These studies suggest that the effect of hormone on interstitial cell gap junctions is to modulate the junctional surface area.

authors

• Burghardt, Robert

published proceedings

• J Cell Biol

author list (cited authors)

• Burghardt, R. C., & Anderson, E.

citation count

• 50

complete list of authors

• Burghardt, RC||Anderson, E

publication date

• April 1979

publisher

• Rockefeller University Press  Publisher

published in

• The Journal of Cell Biology  Journal

keywords

• Animals
• Chorionic Gonadotropin
• Estradiol
• Female
• Freeze Fracturing
• Intercellular Junctions
• Pituitary Gland
• Progesterone
• Rats
• Theca Cells

PubMed Central ID

• 479284

Digital Object Identifier (DOI)

• 10.1083/jcb.81.1.104

start page

• 104

end page

• 114

volume

• 81

issue

• 1

URL

• http://dx.doi.org/10.1083/jcb.81.1.104