Effects of excipients and curing process on the abuse deterrent properties of directly compressed tablets. Academic Article uri icon


  • The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties (ADP) of Polyox based directly compressible abuse deterrent tablet formulations (ADFs). The excipients investigated were lactose (monohydrate or anhydrous), microcrystalline cellulose and hydroxypropyl methylcellulose. The ADPs studied were tablet crush resistance or hardness, particle size distribution following mechanical manipulation, drug extraction in water and alcohol, syringeability and injectability. Other non-ADPs such as surface morphology and tablet dissolution were also studied. It was found that presence of 50% or more of water soluble or swellable excipient in the ADF tablets significantly affected the tablet hardness, particle size distribution following mechanical manipulation and drug extraction while small amount (5%) of excipients had either minimal or no effect on ADPs of these tablets. Addition of high molecular weight HPMC (K 100M) affected syringeability and injectability of ADF. Curing process was found to affect ADPs (hardness, particle size distribution, drug extraction and syringeability and injectability) when compared with uncured tablet. In conclusion, addition of large amount of excipients, especially water soluble ones in Polyox based ADF tablets increase the risk of abuse by various routes of administration.

published proceedings

  • Int J Pharm

author list (cited authors)

  • Rahman, Z., Zidan, A. S., Korang-Yeboah, M., Yang, Y., Siddiqui, A., Shakleya, D., ... Ashraf, M.

citation count

  • 24

complete list of authors

  • Rahman, Ziyaur||Zidan, Ahmed S||Korang-Yeboah, Maxwell||Yang, Yang||Siddiqui, Akhtar||Shakleya, Diaa||Khan, Mansoor A||Cruz, Celia||Ashraf, Muhammad

publication date

  • January 2017