A Novel Physiologically Based Compartmental Model for Volatile Anaesthesia
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This paper presents a dynamic high-fidelity physiologically based model for volatile anaesthesia, taking into account a multiple compartment model of blood and tissue parts, which are individually adjusted to the weight, height, sex and age of the patient. The role of the model is to accurately predict the anaesthetic uptake and distribution depending entirely on the solubilities of the anaesthetic agent in blood and tissue, the individual patient characteristics, and the parameters of the anaesthetic machine set by the anaesthetist. To obtain the significant variables in the model for future parameter estimation and model predictive control, a global sensitivity analysis using Sobol' indices was performed for the variables determining the model. The simulation results of the concentration profiles for enflurane based anaesthesia show important insights in the distribution of the anaesthetic agent in the well and poor perfused compartments. 2011 Elsevier B.V.