Optimal Delivery of Chemotherapeutic Agents in Cancer Academic Article

abstract

• In this paper, derivation of the optimal chemotherapy schedule is formulated and solved as a dynamic optimization problem. For this purpose two models representing the tumour growth kinetics are considered. The dynamic optimization problem for the first model, which is cell cycle non-specific, takes into account multiple time characteristics, drug resistance and toxicity. The discontinuity in the model is formulated by introducing integer variables. For the second model, which is cell cycle specific, the tumour growth is modelled via two compartments: proliferating and resting compartment. 2006 Elsevier B.V. All rights reserved.

authors

• Pistikopoulos, Stratos

published proceedings

• 16TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING AND 9TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING

author list (cited authors)

• Dua, P., Dua, V., & Pistikopoulos, E. N.

citation count

• 3

complete list of authors

• Dua, Pinky||Dua, Vivek||Pistikopoulos, Efstratios N

publication date

• December 2006

publisher

• Elsevier  Publisher

keywords

• Cancer
• Chemotherapy
• Drug Delivery Systems
• Mixed Integer Dynamic Optimization
• Optimal Control

Digital Object Identifier (DOI)

• 10.1016/s1570-7946(06)80283-x

start page

• 1643

end page

• 1648

volume

• 21

issue

• C

URL

• http://dx.doi.org/10.1016/s1570-7946(06)80283-x