Model based parametric control in anesthesia
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This work presents a compartmental model for delivery of three drugs (isoflurane, dopamine and sodium nitroprusside) for regulation of anesthesia. The key feature of this model is that mean arterial pressure, cardiac output and unconsciousness of the patient can be simultaneously regulated. This model is 'validated' by carrying out a number of dynamic state simulations and then used for designing model based parametric controllers. 2005 Elsevier B.V. All rights reserved.