A framework for the design, modeling and optimization of biomedical systems Academic Article uri icon

abstract

  • We present an overview of the key building blocks of a design framework for modeling and optimization of biomedical systems with main focus on leukemia, that we have been developing in the Biological Systems Engineering Laboratory and the Centre for Process Systems Engineering at Imperial College. The framework features the following areas: (i) a three-dimensional, biomimetic, in vitro platform for culturing both healthy and diseased blood; (ii) a novel, hollow fiber bioreactor that upgrades this in vitro platform to enable expansion and continuous harvesting of healthy and diseased blood; (iii) a global optimization-based approach for the design and operation of the aforementioned bioreactor; (iv) a pharmacokinetic / pharmacodynamic model representing patient response to Acute Myeloid Leukemia treatment; (v) an experimental framework for cell cycle modeling and quantitative analysis of environmental stress. This manuscript recapitulates the progress made in the different areas as well as the way in which these areas are connected, finally leading to a hybrid in vitro/in silico platform which allows the optimization of the ex vivo expansion of healthy and diseased blood. 2014 Elsevier B.V.

published proceedings

  • PROCEEDINGS OF THE 8TH INTERNATIONAL CONFERENCE ON FOUNDATIONS OF COMPUTER-AIDED PROCESS DESIGN

author list (cited authors)

  • Velliou, E., Fuentes-Gari, M., Misener, R., Pefani, E., Rende, M., Panoskaltsis, N., Mantalaris, A., & Pistikopoulos, E. N.

citation count

  • 14

complete list of authors

  • Velliou, Eirini||Fuentes-Gari, Maria||Misener, Ruth||Pefani, Eleni||Rende, Maria||Panoskaltsis, Nicki||Mantalaris, Athanasios||Pistikopoulos, Efstratios N

publication date

  • January 2014