A framework for hybrid multi-parametric model-predictive control with application to intravenous anaesthesia
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2015 Elsevier B.V. In this paper we present a framework for the development of hybrid multi-parametric model predictive controllers applied to intravenous anaesthesia. A step-by-step procedure is described featuring a piece-wise model for anaesthesia describing the induction and maintenance phase, a recently developed multi-parametric mixed-integer quadratic programming solver and a novel hybrid control strategy tested for a set of 12 patients.