Global Sensitivity Analysis for a Model of B-Cell Chronic Lymphocytic Leukemia Disease Trajectories Academic Article uri icon

abstract

  • 2015 Elsevier B.V. This paper implements global sensitivity analysis in the Savvopoulos et al. (2014) mathematical model of B cell chronic lymphocytic leukemia (B-CLL); this dynamic model represents a framework for modelling dynamic B-CLL trajectories. B-CLL is a heterogeneous, slowly-progressing disease where a type of white blood cell, B lymphocytes, accumulates in bone marrow, peripheral blood, lymph nodes and spleen. The Savvopoulos et al. (2014) modelling framework integrates both temporal and spatial disease aspects; delay differential equations capture latency in the cell proliferation cycle and population balance equations between disease centres represent inter-tissue B-CLL migration. This manuscript conducts global sensitivity analysis using the random sampling - high dimensional mathematical representation (RS-HDMR) method to: (1) uncover which are the most critical model parameters; (2) analyse the system of model equations; (3) provide clinically-relevant patient testing recommendations leading to effective model parametrisations.

published proceedings

  • 12TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING (PSE) AND 25TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING (ESCAPE), PT A

author list (cited authors)

  • Savvopoulos, S., Misener, R., Panoskaltsis, N., Pistikopoulos, E. N., & Mantalaris, A.

citation count

  • 2

complete list of authors

  • Savvopoulos, Symeon||Misener, Ruth||Panoskaltsis, Nicki||Pistikopoulos, Efstratios N||Mantalaris, Athanasios

publication date

  • January 2015