Computational tools for the advanced control of periodic processes - Application to a chromatographic separation Chapter

abstract

• 2016 Elsevier B.V. In this work we focus on the development of advanced, model-based controllers for periodic processes and we demonstrate their operation capabilities using the example of a chromatographic separation process. We demonstrate the design of a multi-parametric controller for the Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process, a semi-continuous, two-column, periodic chromatographic separation process, governed by a periodic operation profile, linked to production of monoclonal antibodies. For the controller development we use PAROC framework and software platform. The designed controllers are tested in-silico, against the process model and demonstrate stable operation, characterized by cyclic input profiles.

authors

• Pistikopoulos, Stratos

author list (cited authors)

• Papathanasioua, M. M., Oberdieck, R., Mantalaris, A., & Pistikopoulos, E. N.

citation count

• 1

complete list of authors

• Papathanasioua, Maria M||Oberdieck, Richard||Mantalaris, Athanasios||Pistikopoulos, Efstratios N

Book Title

• 26th European Symposium on Computer Aided Process Engineering

publication date

• January 2016

publisher

• Elsevier  Publisher

published in

• Computer Aided Chemical Engineering  Journal

keywords

• Chromatographic Processes
• Control
• Delayed Systems
• Multi-parametric
• Periodic Processes

Digital Object Identifier (DOI)

• 10.1016/B978-0-444-63428-3.50282-4

International Standard Book Number (ISBN) 13

• 9780444634283

start page

• 1665

end page

• 1670

volume

• 38B

URL

• http://dx.doi.org/10.1016/b978-0-444-63428-3.50282-4