Platelet aggregation and adenosine triphosphate secretion in dogs with untreated multicentric lymphoma. Academic Article

abstract

• Whole-blood platelet aggregation and adenosine triphosphate secretion were measured in 15 dogs with untreated multicentric lymphoma and 10 normal control dogs to determine if dogs with lymphoma have altered platelet function. Dogs with quantitative platelet disorders (ie, thrombocytopenia or thrombocytosis) or with clinical evidence of a bleeding disorder were excluded from the study. Platelets from affected dogs had significantly greater maximum aggregation than those from control dogs, suggesting that platelets from dogs with lymphoma are hyperactive. Platelet hyperactivity may play a role in the development of hemostatic disorders (eg, disseminated intravascular coagulation) or in tumor metastasis. Further investigation is needed to determine if modification of platelet function in patients with lymphoma affects disease progression or outcome.

authors

• Rogers, Kenita

published proceedings

• J Vet Intern Med

author list (cited authors)

• Thomas, J. S., & Rogers, K. S.

citation count

• 20

complete list of authors

• Thomas, JS||Rogers, KS

publication date

• July 1999

publisher

• Wiley  Publisher

published in

• Journal of Veterinary Internal Medicine (JVIM)  Journal

keywords

• Adenosine Triphosphate
• Animals
• Dog Diseases
• Dogs
• Female
• Lymphoma
• Male
• Platelet Aggregation

Digital Object Identifier (DOI)

• 10.1892/0891-6640(1999)013<0319:paaats>2.3.co;2

start page

• 319

end page

• 322

volume

• 13

issue

• 4

URL

• http://dx.doi.org/10.1111/j.1939-1676.1999.tb02188.x