Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291 Academic Article uri icon


  • C. difficile infects thousands of hospitalized patients every year, causing significant morbidity and mortality. C. difficile spores play a pivotal role in the transmission of the pathogen in the hospital environment. During infection, the spores germinate, and the vegetative bacterial cells produce toxins that damage host tissue. Thus, sporulation and toxin production are two important traits of C. difficile . In this study, we showed that a mutation in tcdR , the toxin gene regulator, affects both toxin production and sporulation in epidemic-type C. difficile strain R20291.

published proceedings

  • mSphere

altmetric score

  • 5.3

author list (cited authors)

  • Girinathan, B. P., Monot, M., Boyle, D., McAllister, K. N., Sorg, J. A., Dupuy, B., & Govind, R.

citation count

  • 29

complete list of authors

  • Girinathan, Brintha P||Monot, Marc||Boyle, Daniel||McAllister, Kathleen N||Sorg, Joseph A||Dupuy, Bruno||Govind, Revathi

editor list (cited editors)

  • Ellermeier, C. D.

publication date

  • February 2017