-Conglycinin enhances autophagy in porcine enterocytes.
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-Conglycinin (-CG) is well known for inducing intestinal allergies and dysfunction in neonates and young pigs. However, the underlying mechanisms are largely unknown. In this study, to clarify the role of autophagy in -CG-induced cytotoxicity, we investigated the effects of -CG on cell viability and autophagy activity in porcine enterocytes (IPEC-1 cells). The results indicated that the cell viability was decreased with the increasing levels of -CG. -CG treatment enhanced the eGFP-LC3 puncta per cells and LC3-II/LC3-I, and the latter was further increased in IPEC-1 cells cultured with bafilomycin A1. We conclude that -CG enhances autophagy activity in enterocytes.
author list (cited authors)
Yi, D., Hou, Y., Mei, H., Wang, L., Hu, C., & Wu, G.
complete list of authors
Yi, Dan||Hou, Yongqing||Mei, Huimin||Wang, Lei||Hu, Chien-An Andy||Wu, Guoyao