Lactosucrose attenuates intestinal inflammation by promoting Th2 cytokine production and enhancing CD86 expression in colitic rats. uri icon

abstract

  • Some oligosaccharides have immunoregulatory and anti-inflammatory functions in the intestine. This study investigated the immunoregulatory effect of lactosucrose (LS) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitic rats. Alkaline phosphatase activity was increased but myeloperoxidase activity was decreased in the LS-TNBS group, as compared with the TNBS group (colitis rats without receiving LS). LS supplementation stimulated IL-4 and IL-10 production, while up-regulating CD86 expression in dendritic cells. LS supplementation reduced the ratio of CD80/CD86 and the ratio of IFN-/IL-4 compared to the TNBS group. Moreover, IFN- was significantly correlated with CD80 (r=0.764, p<0.01), whereas IL-4 was significantly correlated with CD86 (r=0.489, p<0.05). These results indicated that LS attenuated colitis by promoting the production of Th2-type cytokines and rebalancing the ratio of Th1/Th2 and that enhanced IL-4 production is correlated with enhanced CD86 expression in the gut. Therefore, LS is a functional food for patients with inflammatory bowel disease.

published proceedings

  • Biosci Biotechnol Biochem

altmetric score

  • 1

author list (cited authors)

  • Zhou, Y., Ruan, Z., Zhou, X., Huang, X., Li, H., Wang, L., ... Yin, Y.

citation count

  • 12

complete list of authors

  • Zhou, Yan||Ruan, Zheng||Zhou, Xiaoli||Huang, Xiaoliu||Li, Hua||Wang, Ling||Zhang, Cui||Deng, Zeyuan||Wu, Guoyao||Yin, Yulong

publication date

  • April 2015