Fiber Type-Dependent Suppression of Myocellular Anabolic Response in the Obese Zucker Rat Conference Paper uri icon

abstract

  • The purpose of this study was to determine if insulin resistance syndrome is associated with a blunted myocellular anabolic response (e.g., cumulative protein synthesis rates [24h FSR]) following highintensity resistance exercise (RE). Lean (Fa/?) and obese (fa/fa) 5moold male Zucker rats engaged in 4 sessions of lower body RE and were enriched with 2H2O to assess cumulative FSR in red (RG) and white gastrocnemius (WG). Obese Zucker rats exhibited a significantly higher basal 24h FSR in RG (+22%, P = 0.006) and WG (+ 38%, P = 0.026) compared to the lean phenotype, but were unable to augment protein synthesis rates in WG (7%, P > 0.05) to the same extent as lean rats (+34%, P = 0.027) following RE. Contrary to previous research, mixed muscle protein synthesis rates are enhanced rather than suppressed in selected muscle groups of the obese Zucker rat. Insulin resistance syndrome may impair the myocellular anabolic response following highintensity RE.

published proceedings

  • FASEB JOURNAL

author list (cited authors)

  • Nilsson, M. I., Dobson, J. P., Greene, N. P., Cummins, C. B., McHenry, E., Cloud, W. M., ... Fluckey, J. D.

citation count

  • 0

complete list of authors

  • Nilsson, Mats Inge||Dobson, Justin P||Greene, Nicholas P||Cummins, C Brooke||McHenry, Elaina||Cloud, Whitney M||Wiggs, Michael P||Biehl, Adam J||Fluckey, James D

publication date

  • April 2010

publisher