Pavement friction is one of the primary factors that affect highway safety. Pavements with adequate surface friction reduce the number of wet skidding crashes. The objective of this study was to develop a predictive model for friction loss on pavement surfaces. The model incorporates parameters that describe aggregate shape characteristics, aggregate resistance to abrasion and polishing, aggregate gradation, and polishing cycles. This model was developed on the basis of the results of a comprehensive experimental program. Square-shaped slabs of different asphalt mixtures were prepared in the laboratory by using a linear kneading compactor and polished with a wheel-polishing device. The frictional characteristics of the surface of the test slabs were measured after different intervals of polishing, and statistical analysis was performed to relate friction to mixture and aggregate characteristics.