Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. Academic Article uri icon


  • Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.

published proceedings

  • J Bacteriol

altmetric score

  • 9

author list (cited authors)

  • Sorg, J. A., & Sonenshein, A. L.

citation count

  • 157

complete list of authors

  • Sorg, Joseph A||Sonenshein, Abraham L

publication date

  • February 2009