Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination▿ Academic Article uri icon

abstract

  • Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.

altmetric score

  • 9

author list (cited authors)

  • Sorg, J. A., & Sonenshein, A. L.

citation count

  • 138

publication date

  • December 2008