Hydrogel matrix effects on oxygen diffusion: controlling properties for biosensor applications Conference Paper

abstract

• 2015 IEEE. Oxidoreductase enzymes coupled with oxygensensitive phosphors, when immobilized in injectable polymer hydrogels, provide a minimally-invasive way to transduce levels of biochemical substrates by transcutaneous interrogation. This work evaluates the performance of three hydrogel-based biosensor platforms, all containing glucose oxidase and a tetramethacrylated palladium benzoporphyrin dye as the model enzyme and phosphor, respectively. By characterizing the gel morphology, substrate diffusion kinetics, and overall optical response to glucose, we have elucidated the impact of dye and enzyme solubility as well as morphological homogeneity on overall device performance in vitro.

name of conference

• 2015 IEEE SENSORS

authors

• McShane, Michael

published proceedings

• 2015 IEEE SENSORS

author list (cited authors)

• Unruh, R. M., Weaver, J. L., & McShane, M. J.

citation count

• 0

complete list of authors

• Unruh, RM||Weaver, JL||McShane, MJ

publication date

• January 2015

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

published in

• Proceedings of IEEE Sensors  Journal

keywords

• Biosensor
• Diffusion
• Glucose
• Hydrogel
• Oxygen

Digital Object Identifier (DOI)

• 10.1109/icsens.2015.7370411

International Standard Book Number (ISBN) 13

• 9781479982028

start page

• 930

end page

• 933

URL

• http://dx.doi.org/10.1109/icsens.2015.7370411