ASSESSMENT OF THE DISTRIBUTION AND ELIMINATION OF OCHRATOXIN A IN THE PREGNANT RAT Academic Article uri icon

abstract

  • ABSTRACTThe distribution and elimination of %Hochratoxin A was studied in pregnant rats following s.c. administration of a single dose of 2.5 mg/kg on day 12 of gestation. Elimination of radioactivity from serum was biphasic. The overall elimination (beta) half life was 55.88 h. Fecal elimination of radioactivity accounted for 29.1% of the total radioactivity in the first 24 h and 36.2% in 48 h. Radioactivity in the urine accounted for 6.7% of the total at 24 h and 8.6% at 48 h. Thinlayer chromatography (TLC) of whole fetal extracts demonstrated the presence of the parent compound 12 h after maternal dosing, with peak fetal levels (64.2 ng/g) occurring at 48 h. Virtually all of the radioactivity from the extracts was equivalent to ochratoxin A by TLC. No metabolic congeners of ochratoxin were detected in fetal tissues.

published proceedings

  • JOURNAL OF FOOD SAFETY

altmetric score

  • 6

author list (cited authors)

  • BALLINGER, M. B., PHILLIPS, T. D., & KUBENA, L. F.

citation count

  • 17

complete list of authors

  • BALLINGER, MB||PHILLIPS, TD||KUBENA, LF

publication date

  • May 1986

publisher