ASSESSMENT OF THE DISTRIBUTION AND ELIMINATION OF OCHRATOXIN A IN THE PREGNANT RAT1
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The distribution and elimination of %H‐ochratoxin A was studied in pregnant rats following s.c. administration of a single dose of 2.5 mg/kg on day 12 of gestation. Elimination of radioactivity from serum was biphasic. The overall elimination (beta) half life was 55.88 h. Fecal elimination of radioactivity accounted for 29.1% of the total radioactivity in the first 24 h and 36.2% in 48 h. Radioactivity in the urine accounted for 6.7% of the total at 24 h and 8.6% at 48 h. Thin‐layer chromatography (TLC) of whole fetal extracts demonstrated the presence of the parent compound 12 h after maternal dosing, with peak fetal levels (64.2 ng/g) occurring at 48 h. Virtually all of the radioactivity from the extracts was equivalent to ochratoxin A by TLC. No metabolic congeners of ochratoxin were detected in fetal tissues. Copyright © 1986, Wiley Blackwell. All rights reserved
author list (cited authors)
BALLINGER, M. B., PHILLIPS, T. D., & KUBENA, L. F.
complete list of authors
BALLINGER, MICHAEL B||PHILLIPS, TIMOTHY D||KUBENA, LEON F