Monoclonal antibodies to the bovine immunoglobulin G2a allotypes A1 and A2 Academic Article uri icon

abstract

  • Production of murine monoclonal antibodies (Mabs) to bovine IgG2a-A1 and A2 allotypes resulted in three Mabs being selected as anti-IgG2a-A1 and A2 reagents. Two Mabs recognize the A1 allotype and 1 recognizes the A2 allotype. Initial epitope mapping with the Mabs indicates that one of the A1 epitopes resides in the hinge region and the other epitope resides more toward the C-terminus of the immunoglobulin. The A2 epitope recognized by the A2 Mab does not appear to reside in the hinge region of the immunoglobulin but apparently resides more C-terminal.

author list (cited authors)

  • ESTES, D. M., TEMPLETON, J. W., & ADAMS, L. G.

citation count

  • 4

complete list of authors

  • Estes, DM||Templeton, JW||Adams, LJ

publication date

  • April 1990

publisher