Monoclonal antibodies to the bovine immunoglobulin G2a allotypes A1 and A2. Academic Article

abstract

• Production of murine monoclonal antibodies (Mabs) to bovine IgG2a-A1 and A2 allotypes resulted in three Mabs being selected as anti-IgG2a-A1 and A2 reagents. Two Mabs recognize the A1 allotype and 1 recognizes the A2 allotype. Initial epitope mapping with the Mabs indicates that one of the A1 epitopes resides in the hinge region and the other epitope resides more toward the C-terminus of the immunoglobulin. The A2 epitope recognized by the A2 Mab does not appear to reside in the hinge region of the immunoglobulin but apparently resides more C-terminal.

authors

• Adams, Leslie

published proceedings

• Anim Genet

author list (cited authors)

• Estes, D. M., Templeton, J. W., & Adams, L. J.

citation count

• 4

complete list of authors

• Estes, DM||Templeton, JW||Adams, LJ

publication date

• April 1990

publisher

• Wiley  Publisher

published in

• Animal Genetics  Journal

keywords

• Alleles
• Animals
• Antibodies, Monoclonal
• Cattle
• Enzyme-Linked Immunosorbent Assay
• Epitopes
• Hybridomas
• Immunoglobulin Allotypes
• Immunoglobulin G
• In Vitro Techniques
• Mice

PubMed Central ID

• 1696797

Digital Object Identifier (DOI)

• 10.1111/j.1365-2052.1990.tb03223.x

start page

• 181

end page

• 190

volume

• 21

issue

• 2