A ligation and photorelease strategy for the temporal and spatial control of protein function in living cells. Academic Article uri icon

abstract

  • (Graph Presented) Design and light: A photocleavable synthetic moiety is ligated to the C terminus of a recombinant protein. In the ligated state, the chemical and protein components influence the properties of one another. Upon irradiation with light, both elements are released and their respective function is recovered. In this way a protein can be delivered into living cells and activated by UV irradiation at a desired time or location. 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 6

author list (cited authors)

  • Pellois, J., & Muir, T. W.

citation count

  • 59

complete list of authors

  • Pellois, Jean-Philippe||Muir, Tom W

publication date

  • September 2005

publisher