Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't.
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The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.
author list (cited authors)
Pellois, J., & Muir, T. W.
complete list of authors
Pellois, Jean-Philippe||Muir, Tom W