Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't. Academic Article uri icon


  • The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.

published proceedings

  • Curr Opin Chem Biol

altmetric score

  • 6

author list (cited authors)

  • Pellois, J., & Muir, T. W.

citation count

  • 48

complete list of authors

  • Pellois, Jean-Philippe||Muir, Tom W

publication date

  • October 2006