Early nonsense: mRNA decay solves a translational problem.

abstract

• Gene expression is highly accurate and rarely generates defective proteins. Several mechanisms ensure this fidelity, including specialized surveillance pathways that rid the cell of mRNAs that are incompletely processed or that lack complete open reading frames. One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination--or nonsense--codon. New evidence indicates that the specialized factors that are recruited for this process not only promote rapid mRNA degradation, but are also required to resolve a poorly dissociable termination complex.

authors

• Sachs, Matthew

published proceedings

• Nat Rev Mol Cell Biol

altmetric score

• 8.776

author list (cited authors)

• Amrani, N., Sachs, M. S., & Jacobson, A.

citation count

• 225

complete list of authors

• Amrani, Nadia||Sachs, Matthew S||Jacobson, Allan

publication date

• June 2006

publisher

• Springer Nature  Publisher

published in

• Nature Reviews Molecular Cell Biology  Journal

keywords

• 3' Untranslated Regions
• Animals
• Codon, Nonsense
• Codon, Terminator
• Protein Biosynthesis
• RNA Stability
• RNA, Messenger
• Ribosomes
• Transcription, Genetic

PubMed Central ID

• 16723977

Digital Object Identifier (DOI)

• 10.1038/nrm1942

start page

• 415

end page

• 425

volume

• 7

issue

• 6

URL

• http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm1942