Early nonsense: mRNA decay solves a translational problem. Academic Article uri icon


  • Gene expression is highly accurate and rarely generates defective proteins. Several mechanisms ensure this fidelity, including specialized surveillance pathways that rid the cell of mRNAs that are incompletely processed or that lack complete open reading frames. One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination--or nonsense--codon. New evidence indicates that the specialized factors that are recruited for this process not only promote rapid mRNA degradation, but are also required to resolve a poorly dissociable termination complex.

published proceedings

  • Nat Rev Mol Cell Biol

author list (cited authors)

  • Amrani, N., Sachs, M. S., & Jacobson, A.

complete list of authors

  • Amrani, Nadia||Sachs, Matthew S||Jacobson, Allan

publication date

  • January 1, 2006 11:11 AM