Effect of a methimazole induced hypothyroidism on a growth hormone induced insulin-like growth factor I response in normal and sex-linked dwarf domestic fowl Academic Article uri icon


  • Both normal and dwarf birds were treated with methimazole (MMI) to investigate the effect of low thyroid hormone levels on the synthesis of insulin-like growth factor-1 (IGF-I). MMI treatment resulted in lower thyroid hormone levels in both normal and dwarf birds and in decreased IGF-I levels in normal birds, but not in dwarf animals. An injection of growth hormone (GH) resulted in increased IGF-I levels 24 and 48 hours after injection and this in both normal and dwarf control and MMI fed birds. This increase in IGF-I level swas lower in dwarf and MMI treated birds. Both the smaller increase in birds with low triiodothyronine (T3) levels (dwarfs and MMI treated) and the decrease in T3levels during IGF-I synthesis may be an indication of the role of T3in controlling IGF-I production.

published proceedings

  • Medical Science Research

author list (cited authors)

  • Huybrechts, L. M., Michielsen, R., Darras, V. M., Berghman, L. R., Decuypere, E., & Kuhn, E. R.

complete list of authors

  • Huybrechts, LM||Michielsen, R||Darras, VM||Berghman, LR||Decuypere, E||Kuhn, ER

publication date

  • January 1988