Alterations in chemokine expression following Theiler's virus infection and restraint stress. Academic Article uri icon

abstract

  • Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1 beta, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.

published proceedings

  • J Neuroimmunol

author list (cited authors)

  • Mi, W., Belyavskyi, M., Johnson, R. R., Sieve, A. N., Storts, R., Meagher, M. W., & Welsh, C.

citation count

  • 28

complete list of authors

  • Mi, W||Belyavskyi, M||Johnson, RR||Sieve, AN||Storts, R||Meagher, MW||Welsh, CJR

publication date

  • January 2004