Store-operated CRAC channel inhibitors: opportunities and challenges. Academic Article uri icon

abstract

  • Aberrant Ca(2+) release-activated Ca(2+) (CRAC) channel activity has been implicated in a number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular diseases and cancer, thus placing CRAC channels among the important targets for the treatment of these disorders. We briefly summarize herein the molecular basis and activation mechanism of CRAC channel and focus on discussing several pharmacological inhibitors of CRAC channels with respect to their biological activity, mechanisms of action and selectivity over other types of Ca(2+) channel in different types of cells.

published proceedings

  • Future Med Chem

author list (cited authors)

  • Tian, C., Du, L., Zhou, Y., & Li, M.

citation count

  • 69

complete list of authors

  • Tian, Chengsen||Du, Lupei||Zhou, Yubin||Li, Minyong

publication date

  • May 2016