- Proper treatment of diabetes includes maintenance of near normal blood glucose levels, which can only be achieved with frequent blood glucose monitoring. Current blood finger-stick methods for glucose sensing are invasive, often resulting in low patient compliance and poor disease control. The development of a noninvasive glucose sensor has the potential to provide optimal management of diabetes. Our proposed noninvasive approach is based on an optical polarimetry system for probing the anterior chamber of the eye. The sensor would eventually be used to measure the aqueous humor glucose concentration as a means to determine the blood glucose concentration. In this report, we present the development of a near real-time (less than 1 second) dual wavelength closed-loop polarimetric system to minimize glucose prediction error in the presence of varying birefringence due to motion artifact. The new dual wavelength polarimetric system and in vitro glucose measurement results will be presented which demonstrate the sensitivity and accuracy of the system in the presence of varying birefringence.2009 SPIE.