The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3. Academic Article

abstract

• Two bovine BAC clones were identified by PCR as containing the bovine gene PRKCI. Both clones were assigned by FISH to bands q34-->q36 on BTA1. The sequence information derived from genomic DNA and from both clones was identical and showed a high degree of homology to human PRKCI (HSAXq21.3, 95.5% homology), and mouse Prkcl (MMU3, 13.8 cM, 87.6% homology) and rat Prkcl (88.8% homology). This assignment could suggest a disruption of the synteny conservation of mammalian X-linked genes, but most likely suggests a misassignment of this gene to the human X.

authors

• Stelly, David

published proceedings

• Cytogenet Cell Genet

altmetric score

• 3

author list (cited authors)

• De Donato, M., Gallagher, D. S., Davis, S. K., Stelly, D. M., & Taylor, J. F.

citation count

• 4

complete list of authors

• De Donato, M||Gallagher, DS||Davis, SK||Stelly, DM||Taylor, JF

publication date

• December 2001

publisher

• Karger Publishers  Publisher

published in

• Cytogenetic and Genome Research  Journal

keywords

• Animals
• Cattle
• Chromosomes, Human, Pair 3
• Humans
• In Situ Hybridization, Fluorescence
• Isoenzymes
• Mice
• Physical Chromosome Mapping
• Protein Kinase C
• Rats
• Reproducibility Of Results
• Sequence Homology, Nucleic Acid
• Synteny
• X Chromosome

Digital Object Identifier (DOI)

• 10.1159/000057021

start page

• 79

end page

• 81

volume

• 95

issue

• 1-2

URL

• http://dx.doi.org/10.1159/000057021