Steroid Use in Intervertebral Disc Disease Chapter uri icon


  • © 2015 ACVS Foundation. Glucocorticoids have been used in cases of intervertebral disc disease (IVDD) managed both medically and surgically since the 1960s and have been shrouded in controversy for at least the past 15 years. This chapter discusses the reasons steroids can be useful, the controversy surrounding them, and their effects in the patients. Initial animal models in spinal cord injury (SCI) included rat and feline models. The potentially beneficial mechanism of action of glucocorticoids in SCI is inhibition of this lipid peroxidation as well as hydrolysis, processes that lead to damage of both neuronal and microvascular membranes. The administration of glucocorticoids has been associated with significant side effects, especially in cases of spinal cord disease. There is a significant amount of controversy over the use of glucocorticoids in humans and subsequently in our animal patients as well.

author list (cited authors)

  • Mankin, J. M., & Forterre, F

citation count

  • 1

complete list of authors

  • Mankin, Joseph M||Forterre, Franck

Book Title

  • Advances in Intervertebral Disc Disease in Dogs and Cats

publication date

  • December 2014