Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release.

abstract

• Alginate microspheres loaded with dexamethasone were prepared by the droplet generator technique. Important parameters affecting drug release, including initial drug content, the type of polyelectrolyte coating, and a combination of different ratios of coated and uncoated microspheres were investigated to achieve in vitro dexamethasone delivery with approximately zero order release kinetics, releasing up to 100% of entrapped drug within 1 month, wherein dexamethasone released at a steady rate of 4.83 microg/day after an initial burst release period. These findings imply that these polyelectrolyte-coated alginate microspheres show promise as release systems to improve biocompatibility and prolong lifetime of implantable glucose sensors.

authors

• McShane, Michael

published proceedings

• Drug Deliv

altmetric score

• 6

author list (cited authors)

• Jayant, R. D., McShane, M. J., & Srivastava, R.

citation count

• 43

complete list of authors

• Jayant, RD||McShane, MJ||Srivastava, R

publication date

• January 2009

publisher

• Taylor & Francis  Publisher

published in

• Drug Delivery  Journal

keywords

• Alginates
• Animals
• Cells, Cultured
• Dexamethasone
• Drug Carriers
• Drug Delivery Systems
• Glucuronic Acid
• Hexuronic Acids
• Mice
• Microspheres
• Particle Size
• Polymers

Digital Object Identifier (DOI)

• 10.1080/10717540903031126

start page

• 331

end page

• 340

volume

• 16

issue

• 6

URL

• http%3A%2F%2Fdx.doi.org%2F10.1080%2F10717540903031126