Amphiphilic silicones prepared with branched PEO-silanes with siloxane tethers Academic Article uri icon


  • AbstractAmphiphilic silicones were prepared by the covalent incorporation of branched polyethylene oxide (PEO) via a siloxane tether. This was achieved by using six novel branched PEOsilanes with varying siloxane tether lengths and PEO molecular weight (Mn). Each PEOsilane was crosslinked via acidcatalyzed solgel condensation with ,bis(SiOH)polydimethylsiloxane (PDMS) (Mn = 3000 g/mol) to yield six amphiphilic silicone films. Film surface hydrophilicity increased with siloxane tether length, particularly after exposure to an aqueous environment, indicating that the PEO segments were more readily driven to the surface. This effect was more pronounced for films prepared with PEOsilanes containing lower Mn PEO segments. AFM was used to study surface reconstruction of films upon exposure to an aqueous environment. Adsorption of bovine serum albumin (BSA) and human fibrinogen (HF) proteins decreased with siloxane tether length, particularly after first exposing films to an aqueous environment. For a given siloxane tether length, relatively less BSA adsorbed onto films prepared with PEOsilanes with lower Mn PEO segments whereas less HF adsorbed onto films prepared with PEOsilanes with higher Mn PEO segments. 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 41084119, 2010

published proceedings


author list (cited authors)

  • Murthy, R., Bailey, B. M., Valentin-Rodriguez, C., Ivanisevic, A., & Grunlan, M. A.

citation count

  • 22

complete list of authors

  • Murthy, Ranjini||Bailey, Brennan M||Valentin-Rodriguez, Celimar||Ivanisevic, Albena||Grunlan, Melissa A

publication date

  • September 2010