Templated, Macroporous PEG-DA Hydrogels and Their Potential Utility as Tissue Engineering Scaffolds Academic Article uri icon


  • Poly(ethylene glycol) diacrylate (PEGDA) hydrogels have been widely utilized to investigate cellmaterial interactions and as scaffolds for tissue engineering. Traditionally, PEGDA hydrogels are prepared via the UVcure of aqueous precursor solutions, but afford a limited range of pore size and interconnectivity that is essential for cellular proliferation and neotissue formation. To overcome these limitations, macroporous PEGDA hydrogels are prepared in this study using a combination of solventinduced phase separation (SIPS) and a fused salt template. PEGDA concentration in the organized fabrication solvent (20, 30, and 40 wt%) and average salt particle size (180, 270, and 460 m) are varied and the resulting hydrated hydrogel morphology, swelling, mechanical properties, and degradation are characterized. These templated SIPS PEGDA hydrogels broaden PEGDA hydrogel properties and, in some cases, afford a series of compositions whose properties are decoupled. image

published proceedings


author list (cited authors)

  • Gacasan, E. G., Sehnert, R. M., Ehrhardt, D. A., & Grunlan, M. A.

citation count

  • 9

complete list of authors

  • Gacasan, Erica G||Sehnert, Rebecca M||Ehrhardt, Daniel A||Grunlan, Melissa A

publication date

  • May 2017