Analysis and Control of Genetic Regulatory Systems with Switched Drug Inputs Conference Paper

abstract

• 2016 IEEE. Because cancer usually involves multiple genes and pathways, combination therapy is considered as a promising approach for cancer treatment. However, when multiple drugs are taken by a patient simultaneously, toxicity becomes a concern. A potential solution is to give the drugs sequentially rather than simultaneously. In this study, we try to explore the feasibility of such an approach. Specifically, this study investigates the response of genetic regulatory networks to sequential (switched) drug inputs. The switching mechanism is based on the combination of a state-dependent and time-driven switching function. The design of the switching strategy ensures that the genetic regulatory network will be stabilized and satisfies a decay rate performance index. Simulation results using a mTOR pathway model show the effectiveness of the proposed method.

name of conference

• 2016 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)

authors

• Dougherty, Edward

published proceedings

• 2016 3RD IEEE EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS

author list (cited authors)

• Oduola, W., Li, X., Duan, C., Qian, L., Wu, F., & Dougherty, E. R.

citation count

• 5

complete list of authors

• Oduola, Wasiu||Li, Xiangfang||Duan, Chang||Qian, Lijun||Wu, Fen||Dougherty, Edward R

publication date

• February 2016

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

keywords

• Combination Therapy
• Genetic Regulatory Network
• Switched Systems

Digital Object Identifier (DOI)

• 10.1109/bhi.2016.7455952

International Standard Book Number (ISBN) 13

• 9781509024551

start page

• 533

end page

• 536

URL

• http%3A%2F%2Fdx.doi.org%2F10.1109%2Fbhi.2016.7455952