Comparative analysis of the early transcriptome of Brucella abortus--infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis. Academic Article uri icon

abstract

  • Brucellosis is a worldwide zoonotic infectious disease that has a significant economic impact on animal production and human public health. We characterized the gene expression profile of B. abortus-infected monocyte-derived macrophages (MDMs) from nave cattle naturally resistant (R) or susceptible (S) to brucellosis using a cDNA microarray technology. Our data indicate that (1) B. abortus induced a slightly increased genome activation in R MDMs and a down-regulated transcriptome in S MDMs, during the onset of infection, (2) R MDMs had the ability to mount a type 1 immune response against B. abortus infection which was impaired in S cells, and (3) the host cell activity was not altered after 12 h post-B. abortus infection in R MDMs while the cell cycle was largely arrested in infected S MDMs at 12 h p.i. These results contribute to an improved understanding of how host responses may be manipulated to prevent infection by brucellae.

published proceedings

  • Res Vet Sci

altmetric score

  • 3

author list (cited authors)

  • Rossetti, C. A., Galindo, C. L., Everts, R. E., Lewin, H. A., Garner, H. R., & Adams, L. G.

citation count

  • 20

complete list of authors

  • Rossetti, CA||Galindo, CL||Everts, RE||Lewin, HA||Garner, HR||Adams, LG

publication date

  • August 2011