Autosomal trisomy 20 (61,XX,+20) in a malformed bovine fetus. Academic Article

abstract

• A 240-day-gestation female bovine fetus with severe anasarca, palatoschisis, cheiloschisis, mild cranioschisis, and a flattened facies was collected at a slaughterhouse, and a fibroblast line was established from the fetal skin. Chromosome preparations were Q-banded, and chromosome counts were taken that indicated the presence of 61 chromosomes in cells of the fetus (the normal diploid number for domestic cattle is 60). Q-band karyotypes were constructed, and Q-band analysis revealed the presence of three copies of chromosome 20. Trisomy 20 (61,XX,+20) was confirmed through the use of two-color fluorescence in situ hybridization of bovine bacterial artificial chromosome clones that were specific to chromosome 20 and the X chromosome.

authors

• Edwards, John

published proceedings

• Vet Pathol

author list (cited authors)

• Gallagher, D. S., Lewis, B. C., De Donato, M., Davis, S. K., Taylor, J. F., & Edwards, J. F.

citation count

• 8

complete list of authors

• Gallagher, DS||Lewis, BC||De Donato, M||Davis, SK||Taylor, JF||Edwards, JF

publication date

• September 1999

publisher

• SAGE Publications  Publisher

published in

• Veterinary Pathology  Journal

keywords

• Animals
• Bisbenzimidazole
• Cattle
• Female
• Fetus
• Fluorescent Dyes
• In Situ Hybridization, Fluorescence
• Karyotyping
• Trisomy

PubMed Central ID

• 10490213

Digital Object Identifier (DOI)

• 10.1354/vp.36-5-448

start page

• 448

end page

• 451

volume

• 36

issue

• 5

URL

• http%3A%2F%2Fdx.doi.org%2F10.1354%2Fvp.36-5-448