Phospholipids and terpenes modulate Caco-2 transport of aa anthocyanins. Academic Article uri icon


  • Anthocyanins (ANC) are common polyphenolics in plants, but are poorly absorbed into the bloodstream upon consumption. Phospholipids (PL) and terpenes (TP) may serve as enhancing agents in absorption. This study evaluated their role in transepithelial transport within a Caco-2 cell monolayer-model system and impact on ANC stability. Aa fruit ANC were isolated and found to transport, at a low rate (1.22%), in the absence of soy lecithin phospholipids and Valencia orange terpenes, yet their addition significantly increased the transport of both cyanidin-3-glucoside and cyanidin-3-rutinoside. The best transport results (5.21%) were observed when combinations of PL (5000 mg/l) and TP (50mg/l) were used. The presence of PL and TP had no influence on ANC degradation over a 40 day storage period. Results demonstrated the potential of PL and TP to increase intestinal transport of ANC, and present advancement towards the formulation of functional foods that support improved ANC absorption.

published proceedings

  • Food Chem

author list (cited authors)

  • Cardona, J. A., Mertens-Talcott, S. U., & Talcott, S. T.

citation count

  • 11

complete list of authors

  • Cardona, Jorge A||Mertens-Talcott, Susanne U||Talcott, Stephen T

publication date

  • May 2015