The developmental toxicity of an isolate from the plant Solanum dimidiatum (potato-weed) in Syrian golden hamsters. Academic Article

abstract

• The developmental toxicity of an ethanol extract from Solanum dimidiatum was investigated in date-bred Syrian golden hamsters. Neural tube defects were seen in three Syrian golden hamster fetuses, from one litter out of 12, at a maternal dose of 1.52 mg of plant isolate per g of body weight. Other malformations observed were syndactyly in a single fetus, from one litter out of ten, in the 0.45 mg/g dose group and gastroschisis in a single fetus, from one litter out of nine, in the 1.01 mg/g dose group. These findings suggest minimal developmental toxicity for this plant isolate.

authors

• Bailey, Everett

published proceedings

• Toxicon

author list (cited authors)

• Casteel, S. W., Bailey, E. M., Camp, B. J., Bridges, C. H., Hejtmancik, E., & Ueckert, D. N.

citation count

• 3

complete list of authors

• Casteel, SW||Bailey, EM||Camp, BJ||Bridges, CH||Hejtmancik, E||Ueckert, DN

publication date

• January 1989

publisher

• Elsevier  Publisher

published in

• Toxicon  Journal

keywords

• Animals
• Body Weight
• Cricetinae
• Embryo Implantation
• Female
• Fetal Resorption
• Fetus
• Gestational Age
• Mesocricetus
• Plant Extracts
• Pregnancy
• Solanum Tuberosum
• Teratogens

Digital Object Identifier (DOI)

• 10.1016/0041-0101(89)90042-1

start page

• 757

end page

• 762

volume

• 27

issue

• 7

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0041-0101%2889%2990042-1