The role of lysosomes in the pathogenesis of copper-induced hepatotoxicity: morphological studies. Academic Article

abstract

• Copper-induced hepatotoxicity was evaluated in beige and conventional mice which were injected intraperitoneally with aqueous copper chloride (8 mg per kg body weight per day). Hepatic lesions developed more quickly and were more severe in beige mice and consisted of karyomegaly, progressive accumulation of lipofuscin within hepatocytes and Kupffer cells, acute necrosis of random hepatocytes, and aggregation of leukocytes within the sinusoids. In both groups of mice the hepatic lesion had a centrilobular distribution and closely paralleled the appearance and distribution of copper within hepatocytes. Overall, beige mice had more severe copper-mediated hepatotoxicity, suggesting that normal lysosomes have protective effects for hepatocytes by sequestering copper from other cytoplasmic constituents.

authors

• Adams, Leslie
• Bailey, Everett

published proceedings

• J Comp Pathol

author list (cited authors)

• Helman, R. G., Adams, L. G., Pierce, K. R., Bridges, C. H., & Bailey, E. M.

citation count

• 16

complete list of authors

• Helman, RG||Adams, LG||Pierce, KR||Bridges, CH||Bailey, EM

publication date

• January 1985

publisher

• Elsevier  Publisher

published in

• JOURNAL OF COMPARATIVE PATHOLOGY  Journal

keywords

• Animals
• Chediak-higashi Syndrome
• Chemical And Drug Induced Liver Injury
• Copper
• Cytoplasm
• Disease Models, Animal
• Female
• Hepatolenticular Degeneration
• Injections, Intraperitoneal
• Kupffer Cells
• Lipofuscin
• Liver
• Liver Diseases
• Lysosomes
• Mice
• Mice, Inbred C57BL
• Necrosis

PubMed Central ID

• 3973109

Digital Object Identifier (DOI)

• 10.1016/0021-9975(85)90074-x

start page

• 25

end page

• 35

volume

• 95

issue

• 1

URL

• http://dx.doi.org/10.1016/0021-9975(85)90074-x