Challenges from Variation across Regions in Cost Effectiveness Analysis in Multi-Regional Clinical Trials.
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Economic evaluation in the form of cost-effectiveness analysis has become a popular means to inform decisions in healthcare. With multi-regional clinical trials in a global development program becoming a new venue for drug efficacy testing in recent decades, questions in methods for cost-effectiveness analysis in the multi-regional clinical trials setting also emerge. This paper addresses some challenges from variation across regions in cost effectiveness analysis in multi-regional clinical trials. Several discussion points are raised for further attention and a multi-regional clinical trial example is presented to illustrate the implications in industrial application. A general message is delivered to call for a depth discussion by all stakeholders to reach an agreement on a good practice in cost-effectiveness analysis in the multi-regional clinical trials. Meanwhile, we recommend an additional consideration of cost-effectiveness analysis results based on the clinical evidence from a certain homogeneous population as sensitivity or scenario analysis upon data availability.
author list (cited authors)
Chu, Y., Dai, L., Qi, S., Smith, M. L., Huang, H., Li, Y., & Shen, Y. e.
complete list of authors
Chu, Yunbo||Dai, Luyan||Qi, Sheng||Smith, Matthew Lee||Huang, Hui||Li, Yang||Shen, Ye