Challenges from Variation across Regions in Cost Effectiveness Analysis in Multi-Regional Clinical Trials. Academic Article uri icon


  • Economic evaluation in the form of cost-effectiveness analysis has become a popular means to inform decisions in healthcare. With multi-regional clinical trials in a global development program becoming a new venue for drug efficacy testing in recent decades, questions in methods for cost-effectiveness analysis in the multi-regional clinical trials setting also emerge. This paper addresses some challenges from variation across regions in cost effectiveness analysis in multi-regional clinical trials. Several discussion points are raised for further attention and a multi-regional clinical trial example is presented to illustrate the implications in industrial application. A general message is delivered to call for a depth discussion by all stakeholders to reach an agreement on a good practice in cost-effectiveness analysis in the multi-regional clinical trials. Meanwhile, we recommend an additional consideration of cost-effectiveness analysis results based on the clinical evidence from a certain homogeneous population as sensitivity or scenario analysis upon data availability.

published proceedings

  • Front Pharmacol

altmetric score

  • 0.25

author list (cited authors)

  • Chu, Y., Dai, L., Qi, S., Smith, M. L., Huang, H., Li, Y., & Shen, Y. e.

citation count

  • 0

complete list of authors

  • Chu, Yunbo||Dai, Luyan||Qi, Sheng||Smith, Matthew Lee||Huang, Hui||Li, Yang||Shen, Ye

publication date

  • October 2016