A canine model of multiple portosystemic shunting. Academic Article

abstract

• The objective of this study was to develop and describe an experimental canine model of multiple acquired portosystemic shunts (PSS) similar in nature to spontaneously occurring PSS. Sixteen dogs were used and were divided into a control (n = 6) and a diseased group (n = 10). Dogs of the diseased group were administered dimethylnitrosamine (2 mg/kg of body weight, po) twice weekly, and clinicopathologic, ultrasonographic, and hepatic scintigraphic findings were recorded during the development of hepatic disease and PSS. Surgery was then performed to permit visual verification of multiple shunts, catheter placement for portography examination, and biopsy of the liver. All diseased dogs developed severe hepatic disease and multiple PSS as documented visually at surgery and on portography. Based on this study, dimethylnitrosamine-induced portosystemic shunting appears to be an appropriate model for spontaneously occurring multiple PSS secondary to portal hypertension.

authors

• Howe, Lisa

published proceedings

• J Invest Surg

author list (cited authors)

• Howe, L. M., Boothe, H. W., Miller, M. W., & Boothe, D. M.

citation count

• 9

complete list of authors

• Howe, LM||Boothe, HW||Miller, MW||Boothe, DM

publication date

• January 2000

publisher

• Taylor & Francis  Publisher

published in

• Journal of Investigative Surgery  Journal

keywords

• Animals
• Dimethylnitrosamine
• Disease Models, Animal
• Dogs
• Female
• Liver
• Liver Cirrhosis, Experimental
• Liver Diseases
• Male
• Portasystemic Shunt, Surgical
• Radionuclide Imaging
• Ultrasonography

Digital Object Identifier (DOI)

• 10.1080/089419300272258

start page

• 45

end page

• 57

volume

• 13

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1080%2F089419300272258