The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene. Academic Article uri icon

abstract

  • Many small nuclear RNA gene promoters are activated by SphI postoctamer homology (SPH)-binding factor/selenocysteine tRNA gene transcription activating factor (SBF/Staf). Whereas this transcription factor was initially identified by its ability to bind to SPH elements in such promoters, it was more recently shown to have the capacity to activate transcription of a synthetic mRNA gene promoter through a distinct activation domain. Here, we show that the human interferon regulatory factor-3 (IRF-3) gene promoter contains a functional SPH element that is bound by SBF/Staf in vitro and in transfected cells.

published proceedings

  • J Biol Chem

altmetric score

  • 3

author list (cited authors)

  • Mach, C. M., Hargrove, B. W., & Kunkel, G. R

citation count

  • 20

complete list of authors

  • Mach, Claire M||Hargrove, Brian W||Kunkel, Gary R

publication date

  • February 2002