Influence of Obesity-Related Genotype on Weight Loss Success and Body Composition Changes While Participating in an a 3-Month Exercise and Weight Loss Program: Preliminary Findings
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This study examined whether genotype of some obesityrelated genes (FABP2, PPARG, ADRB279, ADRB246, ADRB3) influences success to different diets while participating in an exercise program. 40 sedentary women (4113 yrs, 35.87.9 kg/m2) were matched according to genotypes favoring carbohydrate restricted and less restricted diets. Diets were 1,500 kcal/d with 20:35:45 and 30:25:45 percentages of C:F:P. Participants performed a circuit style resistanceexercise program (4 d/wk) and a walking program (10,000 steps/d, 3 d/wk). Body weight and DEXA body composition measures were obtained at 0, 4, 8, & 12 wks, analyzed by MANOVA, and are presented as changes from baseline after 12 wks. An overall Wilks' Lambda time x genotype trend was observed (p=0.08) with no time x diet effects (p=0.57). Univariate analysis revealed significant differences between true (T) and false (F) matched genotype groups in fat mass (T: 3.812.5, F: 1.923.2 kg; p=0.013), FFM fat free mass (T:0.761.8, F: 2.162.3; p = 0.042) and body fat (T: 2.152.3, F: 0.012.1 %; p=0.002) with no differences in changes in body weight (T: 4.333.6, F: 3.913.9 kg, p=0.36). These preliminary findings suggest that women participating in a diet and exercise program may experience greater improvements in body composition when diet type is aligned with their genetic profile.
